Some applications of the Indium-113m-transferrin technique for gamma-radiation detection of microvascular effects of serotonin and ischemia
Identifieur interne : 000572 ( Main/Exploration ); précédent : 000571; suivant : 000573Some applications of the Indium-113m-transferrin technique for gamma-radiation detection of microvascular effects of serotonin and ischemia
Auteurs : RBID : ISTEX:433_1987_Article_BF01854968.pdfEnglish descriptors
Abstract
The distribution of systematically injected In-113m (t1/2 = 100 min) in organs of the rat was analyzed, and the use of the isotope for in vivo and in vitro gamma-radiation detection studies of blood plasma protein extravasation was demonstrated in skin, muscle, and tumor.In-113m was slowly excreted from rats. One to 6h after injection the blood held 3% and 2%, respectively, of injected radioactivity/g tissue wet weight; skin and muscle held 0.1%–0.2%/g; liver, colon, and spleen held approximately 1%/g; lungs 1.5%–1.3%/g and kidneys 2.8%–3.3%/g.Scintillation camera technique revealed 40%–80% extraaccumulation of In-113m in a control extremity upon local administration of serotonin and 20%–40% in an extremity with a transplanted tumor, thus indicating a lower effect of serotonin in tumor microvascular circulation than in muscle and skin.In vitro detection of In-113m radiation by a well-counter in dissected tissues showed no effects of serotonin in the tumor and a four- to five-fold increase of radioactivity in muscle and skin, thus confirming blood protein extravasation upon serotonin treatment in these tissues.External analyses of In-113m in the vascular system using one miniaturized probe directed toward an area of interest showed that the method was too sensitive to movements of the animal, and a second probe directed toward a control area is needed.
DOI: 10.1007/BF01854968
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Westergren</name><affiliation wicri:level="1"><mods:affiliation>Dept. of Zoophysiology, University of Lund, Helgonavägen 3B, S-223 62, Lund, Sweden</mods:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Dept. of Zoophysiology, University of Lund, Helgonavägen 3B, S-223 62, Lund</wicri:regionArea><wicri:noRegion>Lund</wicri:noRegion></affiliation></author><author><name>K. Norrgren</name><affiliation wicri:level="1"><mods:affiliation>Dept. of Radiation Physics, Lund University Hospital, Lund, Sweden</mods:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Dept. of Radiation Physics, Lund University Hospital, Lund</wicri:regionArea><wicri:noRegion>Lund</wicri:noRegion></affiliation></author><author><name>L. Lewan</name><affiliation wicri:level="1"><mods:affiliation>Dept. of Zoophysiology, University of Lund, Helgonavägen 3B, S-223 62, Lund, Sweden</mods:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Dept. of Zoophysiology, University of Lund, Helgonavägen 3B, S-223 62, Lund</wicri:regionArea><wicri:noRegion>Lund</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="RBID">ISTEX:433_1987_Article_BF01854968.pdf</idno><date when="1987">1987</date><idno type="doi">10.1007/BF01854968</idno><idno type="wicri:Area/Main/Corpus">000A10</idno><idno type="wicri:Area/Main/Curation">000A10</idno><idno type="wicri:Area/Main/Exploration">000572</idno></publicationStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Indium-113m-transferrin</term><term>Microcirculation</term><term>Rat organs</term><term>Scintillation camera</term><term>Tumor</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="eng">The distribution of systematically injected In-113m (t1/2 = 100 min) in organs of the rat was analyzed, and the use of the isotope for in vivo and in vitro gamma-radiation detection studies of blood plasma protein extravasation was demonstrated in skin, muscle, and tumor.In-113m was slowly excreted from rats. One to 6h after injection the blood held 3% and 2%, respectively, of injected radioactivity/g tissue wet weight; skin and muscle held 0.1%–0.2%/g; liver, colon, and spleen held approximately 1%/g; lungs 1.5%–1.3%/g and kidneys 2.8%–3.3%/g.Scintillation camera technique revealed 40%–80% extraaccumulation of In-113m in a control extremity upon local administration of serotonin and 20%–40% in an extremity with a transplanted tumor, thus indicating a lower effect of serotonin in tumor microvascular circulation than in muscle and skin.In vitro detection of In-113m radiation by a well-counter in dissected tissues showed no effects of serotonin in the tumor and a four- to five-fold increase of radioactivity in muscle and skin, thus confirming blood protein extravasation upon serotonin treatment in these tissues.External analyses of In-113m in the vascular system using one miniaturized probe directed toward an area of interest showed that the method was too sensitive to movements of the animal, and a second probe directed toward a control area is needed.</div></front></TEI><mods xsi:schemaLocation="http://www.loc.gov/mods/v3 file:///applis/istex/home/loadistex/home/etc/xsd/mods.xsd" version="3.4" istexId="b173580a597382ab44b24332f51d78147c7b921d"><titleInfo lang="eng"><title>Some applications of the Indium-113m-transferrin technique for gamma-radiation detection of microvascular effects of serotonin and ischemia</title></titleInfo><name type="personal"><namePart type="given">U.</namePart><namePart type="family">Hultkvist</namePart><role><roleTerm type="text">author</roleTerm></role><affiliation>Dept. of Zoophysiology, University of Lund, Helgonavägen 3B, S-223 62, Lund, Sweden</affiliation></name><name type="personal"><namePart type="given">G.</namePart><namePart type="family">Westergren</namePart><role><roleTerm type="text">author</roleTerm></role><affiliation>Dept. of Zoophysiology, University of Lund, Helgonavägen 3B, S-223 62, Lund, Sweden</affiliation></name><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Norrgren</namePart><role><roleTerm type="text">author</roleTerm></role><affiliation>Dept. of Radiation Physics, Lund University Hospital, Lund, Sweden</affiliation></name><name type="personal"><namePart type="given">L.</namePart><namePart type="family">Lewan</namePart><role><roleTerm type="text">author</roleTerm></role><affiliation>Dept. of Zoophysiology, University of Lund, Helgonavägen 3B, S-223 62, Lund, Sweden</affiliation></name><typeOfResource>text</typeOfResource><genre>Original Papers</genre><genre>Original Paper</genre><originInfo><publisher>Springer-Verlag, Berlin/Heidelberg</publisher><dateCreated encoding="w3cdtf">1986-06-30</dateCreated><dateCaptured encoding="w3cdtf">1986-09-15</dateCaptured><dateValid encoding="w3cdtf">2005-05-30</dateValid><copyrightDate encoding="w3cdtf">1987</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="eng">The distribution of systematically injected In-113m (t1/2 = 100 min) in organs of the rat was analyzed, and the use of the isotope for in vivo and in vitro gamma-radiation detection studies of blood plasma protein extravasation was demonstrated in skin, muscle, and tumor.In-113m was slowly excreted from rats. One to 6h after injection the blood held 3% and 2%, respectively, of injected radioactivity/g tissue wet weight; skin and muscle held 0.1%–0.2%/g; liver, colon, and spleen held approximately 1%/g; lungs 1.5%–1.3%/g and kidneys 2.8%–3.3%/g.Scintillation camera technique revealed 40%–80% extraaccumulation of In-113m in a control extremity upon local administration of serotonin and 20%–40% in an extremity with a transplanted tumor, thus indicating a lower effect of serotonin in tumor microvascular circulation than in muscle and skin.In vitro detection of In-113m radiation by a well-counter in dissected tissues showed no effects of serotonin in the tumor and a four- to five-fold increase of radioactivity in muscle and skin, thus confirming blood protein extravasation upon serotonin treatment in these tissues.External analyses of In-113m in the vascular system using one miniaturized probe directed toward an area of interest showed that the method was too sensitive to movements of the animal, and a second probe directed toward a control area is needed.</abstract><subject lang="eng"><genre>Key words</genre><topic>Indium-113m-transferrin</topic><topic>Scintillation camera</topic><topic>Rat organs</topic><topic>Microcirculation</topic><topic>Tumor</topic></subject><relatedItem type="series"><titleInfo type="abbreviated"><title>Res. Exp. Med.</title></titleInfo><titleInfo><title>Research in Experimental Medicine</title><partNumber>Year: 1987</partNumber><partNumber>Volume: 187</partNumber><partNumber>Number: 1</partNumber></titleInfo><genre>Archive Journal</genre><originInfo><dateIssued encoding="w3cdtf">1987-01-01</dateIssued><copyrightDate encoding="w3cdtf">1987</copyrightDate></originInfo><subject usage="primary"><topic>Medicine & Public Health</topic><topic>Internal Medicine</topic></subject><identifier type="issn">0300-9130</identifier><identifier type="issn">Electronic: 1433-8580</identifier><identifier type="matrixNumber">433</identifier><identifier type="local">IssueArticleCount: 10</identifier><recordInfo><recordOrigin>Springer-Verlag, 1987</recordOrigin></recordInfo></relatedItem><identifier type="doi">10.1007/BF01854968</identifier><identifier type="matrixNumber">Art7</identifier><identifier type="local">BF01854968</identifier><accessCondition type="use and reproduction">MetadataGrant: OpenAccess</accessCondition><accessCondition type="use and reproduction">AbstractGrant: OpenAccess</accessCondition><accessCondition type="restriction on access">BodyPDFGrant: Restricted</accessCondition><accessCondition type="restriction on access">BodyHTMLGrant: Restricted</accessCondition><accessCondition type="restriction on access">BibliographyGrant: Restricted</accessCondition><accessCondition type="restriction on access">ESMGrant: Restricted</accessCondition><part><extent unit="pages"><start>49</start><end>54</end></extent></part><recordInfo><recordOrigin>Springer-Verlag, 1987</recordOrigin><recordIdentifier>433_1987_Article_BF01854968.pdf</recordIdentifier></recordInfo></mods></record>Pour manipuler ce document sous Unix (Dilib)
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